On August 5, the State Council held a regular policy briefing on the theme of improving the ability to detect new corona virus. At the meeting, it emphasized accelerating the development of antigen detection products. Compared with antibody detection, antigen detection products can be detected earlier and can be used as A direct evidence of the existence of the new corona virus, so speeding up the development of antigen products will help enrich our country's detection technology.

Faster and more economical antigen detection can diagnose active infection by finding early virulent traces of the virus instead of the genetic code of the virus itself. It can quickly detect viral protein fragments in swab samples taken from the nostril or throat, automatically provide accurate results within 15 minutes , which speed up the diagnosis time and treatment speed, and diagnose whether the new corona virus is infected in a short time without expensive equipment, training and skills. Compared with nucleic acid detection reagents, antigen detection reagents have lower cost, more convenient operation, and shorter time, which are more conducive to the detection of COVID-19 in low and middle income countries/regions.


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Principle of antigen detection reagent

Antigen detection is to first prepares N protein or S protein from the new corona virus, then immunizes animals such as mice, rabbits, etc. to obtain monoclonal antibodies or polyclonal antibodies against the corresponding antigen, and then make these antibodies into a test kit to detect the concentration value of the corresponding antigen in patients with new corona pneumonia. This antigen detection method can be used as an indicator for early detection of COVID-19.


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Schematic diagram of antigen rapid detection test strip

 

The core technical method of antigen detection

Mainly POCT technology includes immunochromatographic colloidal gold method, immunochromatographic fluorescence method and high-throughput chemiluminescence technology. The former qualitatively or semi-quantitatively detects neocoronavirus antigens; the latter quantitatively and high-throughputly detects neocoronavirus antigens. The antigens currently being tested include N-protein and S-protein.

The performance of test products directly affects the test results, so a full range of high-quality test reagent production equipment and raw materials are the key to producing high-quality test products.

Since the development of Kinbio for nearly 20 years, it has always focused on the scientific research, innovation and development of the IVD industry, and has taken the pursuit of product quality and customer service as its own responsibility. The full range of production equipment for rapid diagnostic test strips provided by Kinbio includes R&D and production phases. It can provide customers with different production needs with the most suitable production plan, including reagent solution coating equipment, cutting equipment, laminating equipment (roll + card type), assembly rolling equipment, reagent filling equipment, automatic cassette assembly and packaging equipment and laser coding equipment, etc.

During the epidemic, the full range of production lines developed by Kinbio have provided production solutions for many well-known IVD companies.


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Production equipment recommendation form for reference:


CategoryEquipment NameTechnical ParametersUsage
Reagent solution coating equipmentXYZ Platform Dispenser and Sprayer HM3035Dispensing efficiency of single pump:200-300 sheets (30cm)/h;Spraying efficiency of single pump:700-900 lines (30cm)/hDispensing and spraying can be automatically switched
Cutting EquipmentProgrammable Sheet Cutter CTS300Maximum cutting speed:280 times/min;Width:5-50mmConsumables cutting
Strip Cutter ZQ3502Maximum cutting speed:450 times / min;Sheet width≤98mmUncut sheet cutting, can be fed automatically
Laminating EquipmentReel to Card Laminator and Dispenser CTM650+HM8008Backing width:45-98mmCutting length:260-600mmRunning speed:50-200mm/s(10-40 sheets/min)Continuous laminating and dispensing of roll type consumables
Assembly Rolling EquipmentAssembly Roller YK725Running speed:0-15 meters/minCassettes pressing
Filling and Labeling EquipmentFilling machine GZ350-1Filling accuracy of gradient pump:≤±1%;Filling accuracy of peristaltic pump pump:≤±3%;Filling efficiency:35-45pcs/minFilling and labeling of biochemical, immunological and molecular diagnostic reagents
Side vertical labeling machine CLT500Labeling efficiency:50-80pcs/min;Label width:8-40mm;Label length:12-55mm

 

Among them, filling machines and strip assembling and packaging machines in non-standard automation equipment are favored by many IVD testing reagent manufacturers, which improved their production efficiency and are the first choice of many mass production IVD companies. The equipment uses an automatic control system to perform a series of automatic operations from cutting test strips to strip assembly, cassette packaging, sealing, and coding to complete mass production requirements and can be customized according to customer needs.


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Full automatic strip assembling machine and packaging machine

At the same time, we can also provide a full set of high-quality diagnostic test strip production consumables, including backing card, glass fiber, polyester fiber , special absorbent paper, NC membrane, protective film strips, etc.


Consumables TypeModel RecommendedParametersUsage
Plastic backing cardSM31-25Thickness:25mm;Single side glueStrip backing
Glass fiberSB08Thickness 0.32-0.48mm;Climb speed 15-32mm/60sConjugate pad or sample pad
RB65Thickness 0.25-0.35mmClimb speed 20-45mm/60s
Polyester fiberVL98Thickness 0.25-0.35mmClimb speed 15-40s/4cmConjugate pad
DL42Thickness 0.37-0.53mmClimb speed 20-160s/4cm
Special absorbent paperCH37Thickness 0.87-1.13mmClimb speed 40-180s/4cmAbsorbent pad

 

From initial research and development to the transformation of scientific research results, Kinbio provides turnkey engineering services for immunochromatographic test strips, which can provide a complete set of immunochromatographic test strip production line solutions for IVD companies, including a series of immunochromatographic technology training, antigen/antibody various technical services such as raw material evaluation, colloidal gold test strip technology transfer, commissioned personnel training and technical service consulting. According to customer needs, Kinbio can undertake a series of services such as the design of a complete set of colloidal gold test strip R&D and production workshops and standardized laboratories, equipment selection, installation and commissioning, production process flow, etc., and provide corresponding technology transfer according to the actual needs of customers.

If you have a demand for the full range of new corona testing products, production equipment and consumables, Kinbio can provide you with high-quality related products and high-quality after-sales service, jointly help the global epidemic prevention and control work, and make a contribution to building a global community with a shared future .

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Little Test Strip Has Great Energy | The Full Range Production Line Equipment and Consumables Of Kinbio Rapid Diagnostic Test Strip